Before & After Photos Of Serena Williams’ Ozempic Transformation

Before & After Photos Of Serena Williams’ Ozempic Transformation

February 21, 2026 discoverhiddenusacom Health

The use of GLP-1 medications, often referred to as Ozempic, has entered the mainstream, and its impact is being felt even among high-profile figures like tennis legend Serena Williams. Revealed during a Superbowl LX commercial break, Williams’ use of the drug—a Semaglutide injection initially prescribed for diabetes—has sparked conversation about its role in weight loss and body image. Williams has reportedly lost over 31 pounds since beginning the medication.

Serena Williams and the Rise of GLP-1s

Williams’ openness about her experience sets her apart from many celebrities who have been more discreet about using these drugs. As a global ambassador for telehealth company Ro, her weight loss journey has been highly visible. In an interview on the Oprah podcast, Williams described struggling to lose postpartum weight despite an intense training regimen of eight hours a day in the gym. She has since shared that after a year on the drug, she “feels lighter mentally, feels sexier, feels more confident” (via Vogue).

Did You Know? Serena Williams reportedly could not lose “an ounce” despite working out for eight hours a day in preparation for her last match at the Open.

A Complex Relationship

The situation is further complicated by the financial ties between Williams’ family and Ro. Her husband, Alexis Ohanian, co-founder of Reddit, was an early investor in Ro and has served on their board since 2017. While Williams has emphasized her commitment to transparency and stated, “I had never taken shortcuts in my career and always worked really hard” (via People), her commercials for Ro present GLP-1s not as a shortcut, but as “science.”

Expert Insight: The intersection of celebrity endorsement, personal investment, and a potentially transformative medication raises questions about the influence of financial incentives on public health messaging. While Williams’ experience is personal, her platform amplifies the reach of these drugs and their associated narratives.

Despite maintaining a vigorous workout routine, Williams’ transformation has drawn comparisons to other celebrities whose appearances have changed after using Ozempic. However, the accessibility of these drugs remains limited, with financial constraints and supply issues preventing widespread, long-term use. This raises concerns about her role as a role model for aspiring athletes.

Some fans have expressed feelings of betrayal, with one Redditor sharing that Williams’ endorsement suggests something was “wrong with her body before—when she was the best in the world”—and that the drug will “correct” it.

Frequently Asked Questions

What is a GLP-1?

GLP-1s are Semaglutide injections typically prescribed to diabetic patients, but have gained attention for their weight-loss side effect.

How much weight has Serena Williams lost?

Serena Williams has lost over 31 pounds since starting to take GLP-1s.

What is the connection between Serena Williams and the company Ro?

Serena Williams is a global ambassador for Ro, and her husband, Alexis Ohanian, has been an investor in and board member of the company since 2017.

As the conversation around GLP-1s continues, it remains to be seen how their long-term effects will be understood and whether their use will become more normalized or remain a topic of debate.