Multi-country outbreak of cholera, epidemiological update #33 -27 January 2026

Global health authorities are tracking a significant outbreak of cholera, an acute diarrheal infection, impacting multiple regions. Data collected through December 28, 2025, reveals a widespread public health challenge with cases reported across 33 countries.

Cholera’s Global Reach in 2025

From January 1 to December 28, 2025, a cumulative total of 614,828 cholera cases were reported. Tragically, these cases resulted in 7,598 deaths. The impact is not uniform, with five WHO regions affected: the Eastern Mediterranean Region experienced the highest number of cases, followed by the African Region, the South-East Asia Region, the Region of the Americas, and the Western Pacific Region.

Regional Variations

Notably, the European Region reported no cases during this period. This highlights the varying levels of risk and preparedness across different geographical areas. The Eastern Mediterranean Region is currently bearing the heaviest burden of this outbreak.

Did You Know? Cholera cases were reported in 33 countries across five WHO regions between January 1 and December 28, 2025.

Recent Trends and Potential Trajectories

Recent data indicates a possible shift in the outbreak’s trajectory. In December 2025 alone (epidemiological weeks 49 to 52), 17,327 new cases of cholera and acute watery diarrhoea (AWD) were reported across 16 countries within three WHO regions. This represents a 25% decrease compared to the number of cases reported in November.

The number of deaths also saw a decline. A total of 137 cholera-related deaths were reported globally in December 2025, a 16% decrease from the previous month. While these decreases are encouraging, the situation remains critical.

Expert Insight: The reported decreases in both cases and deaths during December 2025, while positive, do not negate the overall severity of the ongoing cholera upsurge. Continued vigilance and sustained public health interventions are crucial to prevent a resurgence and protect vulnerable populations.

The current upsurge, which began in 2021, continues to demand attention and resources. Further monitoring is essential to understand the evolving dynamics of the outbreak.

Frequently Asked Questions

What is the current scale of the cholera outbreak?

From January 1 to December 28, 2025, a cumulative total of 614,828 cholera cases and 7,598 deaths were reported from 33 countries across five WHO regions.

Which regions are most affected?

The Eastern Mediterranean Region recorded the highest numbers of cases, followed by the African Region, the South-East Asia Region, the Region of the Americas, and the Western Pacific Region. No cases were reported from the European Region.

Are case numbers increasing or decreasing?

In December 2025, there was a 25% decrease in new cholera and acute watery diarrhoea cases compared to November. Deaths also decreased by 16% during the same period.

What factors might influence the future course of this outbreak, and how can communities best prepare for potential challenges?