New drug could fight ‘Ozempic butt’ and other unwelcome side effects

An experimental antibody medication called apitegromab may allow users of GLP-1 weight-loss drugs to lose weight without sacrificing muscle mass, according to a study published in Nature Medicine. Research led by coauthor Richard Pratley found that patients using the drug retained approximately 55% more lean mass compared to those using weight-loss medications alone.

Why do GLP-1 drugs cause muscle loss?

Weight-loss medications like Wegovy and Zepbound mimic hormones to stabilize blood sugar and reduce food cravings. While these drugs trigger significant weight loss, research suggests 25% to 40% of that loss comes from lean body mass, including muscle.

This muscle depletion can lead to “Ozempic butt,” a condition characterized by a sudden loss of volume in key areas. Lean body mass is critical for maintaining metabolism, balance, mobility, and energy levels.

How does apitegromab preserve lean mass?

Apitegromab works by blocking myostatin, a protein that contributes to the breakdown of muscle. In a clinical trial of 102 overweight or obese participants, researchers tested the drug alongside weekly injections of tirzepatide, sold as Mounjaro and Zepbound.

According to Richard Pratley, the results “absolutely show that they can preserve lean mass.” While both trial groups lost similar amounts of weight, those receiving monthly apitegromab infusions retained about 55% more muscle.

This retention also affected physical performance. Participants taking apitegromab recorded higher scores in leg strength and endurance, as well as slightly greater grip strength.

What are the alternatives for maintaining muscle?

Experts recommend adults engage in at least 150 minutes of moderate-intensity aerobic exercise per week. This should be paired with at least two days of strength training, such as resistance training or lifting weights.

Dietary protein is also necessary. The Recommended Dietary Allowance is 0.8 grams of protein per kilogram of body weight, though those building muscle may need between 1.2 and 2 grams per kilogram.

High-protein sources include tofu, chickpeas, lentils, salmon, tuna, chicken, turkey, and yogurt. Experts warn that high intake of red meat may increase the risk of prostate, pancreatic, and colorectal cancers.

What happens next for this medication?

Apitegromab has not been approved by the US Food and Drug Administration and currently requires intravenous infusions. Researchers are exploring the drug as a potential treatment for spinal muscular atrophy.

Future studies may determine if the medicine could combat sarcopenia, the age-related loss of muscle and strength. According to Seeley, the goal is finding “the right drug for the right patient at the right time.”

Frequently Asked Questions

What is “Ozempic butt”?
It is a symptom of rapid weight loss characterized by a sudden loss of muscle and volume in the backside, leaving users feeling and looking deflated.

How much muscle is typically lost on GLP-1 drugs?
Research suggests that about 25% to 40% of the weight lost during GLP-1 treatment comes from lean body mass.

Is apitegromab available for public use?
No. It is an experimental medication that has not been approved by the FDA and is only available via intravenous infusions.

Would you prioritize faster weight loss or the preservation of muscle mass during a health transformation?