NutriNet-Santé: Preservative Food Additives Associated With Increased HTN, CVD Incidence
Recent research has identified a concerning link between the consumption of preservative food additives found in industrial foods and an increased risk of developing cardiovascular issues. The findings suggest that these common additives may contribute to a higher incidence of hypertension and cardiovascular disease.
The Scope of the Research
The analysis involved 112,395 participants in France between 2009 and 2024, with an average age of 42 years. The group was composed of 79% women.
Researchers tracked dietary habits using repeated 24-hour records, some totaling up to 96 entries. This process included the analysis of commercial brands, compositional databases, and laboratory assays of food matrices.
Key Findings on Heart Health
The study evaluated the cumulative exposure to 58 different preservative substances. A significant correlation was found regarding non-antioxidant preservatives.
Participants with higher consumption of these preservatives compared to those with lower consumption faced a 29% higher risk of hypertension and a 16% higher risk of cardiovascular disease. Higher consumption of total non-antioxidant preservatives was associated with a 22% higher risk of hypertension.
Out of the 17 most common preservative additives—those consumed by at least 10% of the participants—eight were linked to an increased risk of hypertension, while one was associated with a higher risk of cardiovascular disease.
Potential Future Implications
Because these substances are so prevalent in the modern diet, these results could have important public health implications. The widespread nature of these additives means a large portion of the population is likely exposed to them daily.
A possible next step for the scientific community is the pursuit of additional epidemiological studies to confirm these results. Researchers may also seek more experimental data to better understand the specific mechanisms that could cause these adverse cardiovascular and hypertension-related effects.
Frequently Asked Questions
Who was included in the study?
The study analysed 112,395 participants in France from 2009 to 2024, with a mean age of 42 years and a participant base that was 79% women.

What risks are associated with non-antioxidant preservatives?
Higher consumption of total non-antioxidant preservatives was associated with a 22% higher risk of hypertension. When comparing higher consumption to lower consumption, there was a 29% higher risk of hypertension and a 16% higher risk of cardiovascular disease.
How common are these additives in the diet?
The research found that 99.5% of participants consumed at least one food preservative within the first two years of the follow-up, and these compounds are found in thousands of foods and drinks.
How often do you check the ingredient labels of your favorite packaged foods for preservatives?