Using GLP-1s at a normal BMI? There are benefits and risks : NPR

Christie Woodard, 53, of Easton, Maryland, is an avid runner with a remarkable story of weight loss, health challenges and the evolving landscape of obesity treatment. After undergoing gastric bypass surgery four years ago, Woodard achieved a healthy weight of 125 pounds, but recently found herself regaining weight despite diligent diet and exercise. This led her physician to prescribe a low dose of the drug Zepbound, even though her body mass index didn’t technically classify her as overweight.

A Complex Relationship with Weight and Medication

Woodard’s journey began with struggles with obesity, reaching a weight of 260 pounds. She initially felt shame about needing medication to maintain her weight loss, questioning whether it signaled a personal failure. However, she came to view GLP-1s not as a cosmetic fix, but as a tool to manage a chronic condition, similar to how statins are used for cholesterol. She successfully advocated for GLP-1 coverage in her employer’s health insurance plan, citing the reduction in related medical costs.

Did You Know? Christie Woodard is currently running half-marathons in all 50 states, having completed 34 as of February 12, 2026.

The Expanding Use of GLP-1s

Woodard’s case reflects a growing trend: the use of GLP-1 receptor agonists, like Zepbound, even among individuals who are not traditionally considered obese. While these drugs are designed to treat metabolic diseases like diabetes and obesity, some individuals are seeking them for weight management, fueled by increasing availability and affordability. The rise of compounded versions and online sellers also makes access easier, even for those without a clear medical need.

Dr. Betsy Dovec, Woodard’s bariatric surgeon, notes that she prescribes GLP-1s to a variety of patients, but emphasizes that she does not prescribe them for purely cosmetic reasons. However, other experts, like Dr. Jennifer Manne-Goehler, express concern that wider access could lead to misuse and potential health risks, including muscle loss and weight regain upon stopping the medication.

Expert Insight: The increasing use of GLP-1s outside of traditional obesity treatment raises questions about the potential for unintended consequences, including the cyclical pattern of weight loss and regain, and the need for careful patient evaluation to identify those who may be at risk for disordered eating.

Navigating a Shifting Landscape

The debate surrounding GLP-1s highlights the complexities of weight management and the evolving understanding of obesity as a chronic disease. Woodard’s experience underscores the importance of individualized treatment plans that may include surgery, diet, exercise, and medication. She believes that feeling in control of her weight has boosted her confidence and overall well-being, impacting all aspects of her life.

Frequently Asked Questions

What prompted Christie Woodard to begin using GLP-1 medication?

Christie Woodard began using Zepbound after experiencing weight regain despite maintaining a strict diet and exercise regimen following gastric bypass surgery.

Is Dr. Dovec concerned about prescribing GLP-1s to patients who are not technically obese?

Dr. Dovec states she prescribes medications for all types of people and does not prescribe the drugs for purely aesthetic reasons.

What are some potential risks associated with GLP-1 use, according to Dr. Manne-Goehler?

Dr. Manne-Goehler notes that people using GLP-1s may lose muscle mass first and regain fat when they stop using the drug, potentially leading to harmful yo-yo dieting effects.

As Woodard continues her journey to run a half-marathon in every state, her story offers a glimpse into the changing approaches to weight management and the ongoing conversation about the role of medication in achieving and maintaining a healthy lifestyle.