Modeling neurotropic viral infections using human cerebral organoids
Research into how viruses that target the nervous system impact the developing brain has faced significant hurdles. These challenges stem from limited access to fetal tissue for study and the inherent difficulty in visualizing the brain’s complex, three-dimensional structures. However, a new approach utilizing human cerebral organoids—lab-grown models that mimic the developing human brain—is offering a promising pathway to overcome these obstacles.
A New Model for Understanding Brain Development
Cerebral organoids provide a physiologically relevant, three-dimensional environment for studying the effects of viral infections on the developing brain. This allows researchers to observe tissue-level changes over the course of a sustained infection, something previously difficult to achieve.
Focus on Zika Virus and Neurodevelopmental Injury
A webinar featuring Rodrigo Cristofoletti, PhD, Associate Professor and Director at the University of Florida, and Michael Furtaw, PhD, Vice President of Research and Development at LICORbio, will specifically address the impact of Zika virus infection on these cerebral organoids. The discussion will centre on how the virus affects both the growth and the structural integrity of the organoids.
Advanced Imaging and Analysis
The webinar will also explore the advanced imaging and analytical techniques used to investigate neurodevelopmental injury. These techniques include large-area imaging and histological analysis of the 3D brain models. Scalable workflows for studying neurotropic viral infections will also be a key topic.
What Could Happen Next
Following this webinar, researchers may utilize the discussed scalable workflows to investigate a wider range of neurotropic viruses and their effects on brain development. It is also likely that further refinements to cerebral organoid technology will enhance their fidelity and predictive power. A possible next step could involve comparing findings from organoid studies with data from clinical cases to validate the models’ relevance.
Frequently Asked Questions
What is a cerebral organoid?
A cerebral organoid is a three-dimensional, lab-grown model that mimics the developing human brain.
What virus will be the focus of the webinar?
The webinar will focus on the effects of Zika virus infection.
Who are the speakers for this webinar?
The speakers are Rodrigo Cristofoletti, PhD, and Michael Furtaw, PhD.
How might advancements in modelling brain development impact our understanding of neurological conditions?