Why Setting Weight Loss Goals May Be Key to Success
Patients using tirzepatide—the active ingredient in Zepbound and Mounjaro—may achieve greater weight loss by setting personal targets, according to research presented at ENDO 2026. The study found that females and individuals who previously attempted structured diet plans were more likely to reach significant weight loss milestones than males or those without goals.
The research, presented in Chicago from June 13–16, analyzed data from 80,942 individuals with an average age of 43. Of the total group, 21,490 participants reached a six-month follow-up, and 4,429 were included in the 12-month follow-up.
Study author Hans Johnson, research lead in the Department of Clinical Research and Innovation at Voy, stated in a press release that these findings could help physicians tailor support and counsel patients on realistic expectations.
Why do personal goals improve GLP-1 results?
Goal setting addresses the behavioral components of weight loss that medication alone may not cover. Nicole Andreoli, PhD, a licensed psychologist with Pathway Psychological Services, told Healthline that while GLP-1 drugs handle biological appetite and “food noise,” goals provide direction and focus.
Andreoli noted that setting targets helps patients maintain commitment and consistency. This process allows individuals to monitor progress and make intentional choices throughout their treatment.
How do sex and health history affect weight loss?
The data indicates sex-specific differences in medication response. Females were significantly more likely than males to achieve a 20% total body weight loss by the 12-month follow-up.
Previous behavior also played a role. Individuals who had attempted structured diet plans before starting tirzepatide achieved a higher percentage of weight loss.
Conversely, patients with pre-existing conditions, including type 2 diabetes, were less likely to hit the 20% weight loss target by the end of the 12-month period.
What strategies support long-term success?
Medical experts warn that weight regain may occur after patients stop taking GLP-1 medications. Mir Ali, MD, medical director of MemorialCare Surgical Weight Loss Center, emphasizes reducing sugar and carbohydrate intake while prioritizing vegetables and proteins to encourage the body to burn fat.
Dr. Ali also recommends regular exercise, such as walking, to minimize muscle loss during the weight loss process. He stated that patients who actively work toward realistic goals through lifestyle changes are more likely to see significant benefits.
Psychologist Nicole Andreoli suggests using the medication period to rebuild healthy eating patterns. She advises patients to pay attention to internal cues for hunger and fullness and identify emotional factors that influence eating habits.
What may happen next for patients?
Physicians may begin incorporating additional behavioral interventions for patients who face motivational barriers. According to Hans Johnson, this tailored approach could ensure that medication is paired with the necessary psychological support to reach weight targets.
Patients may also see a shift toward more personalized prescriptions that account for sex-specific differences in weight loss outcomes.
Frequently Asked Questions
Who experienced the most weight loss in the tirzepatide study?
Females and individuals who set baseline weight loss goals or had previously attempted structured diet plans achieved greater weight loss results.
What was the total number of participants in the research?
The study analyzed data from 80,942 individuals with an average age of 43.
What lifestyle changes do experts recommend alongside GLP-1 drugs?
Experts recommend reducing carbohydrates and sugar, prioritizing proteins and vegetables, and engaging in regular exercise like walking to prevent muscle loss.
Do you believe setting a specific target changes how you approach a health goal?